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Welcome
to
The
Modeling of Visual Transduction at Vanderbilt
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| Visual
transduction occurs by precise,
highly-regulated localization of key enzymes in the photoreceptor. Classical methods assume a well-stirred environment and thus
do not describe the local effects emanating from these
highly-organized structures. Such a
complexity calls for mathematical models of signal transduction for
critical evaluation of the data, for quantitative understanding of
the processes, and for designing discriminating experiments. A team
of mathematicians, biologists, and computational scientists develop
spatio-temporal mathematical models of prototype signal
transduction pathways. The models are formulated, analyzed
mathematically, implemented into computer codes, and predicted
results are compared with known biological data. In this
iterative process, the model is critically tested and modified
accordingly. Our long term goal is to produce validated
computational models of signal transduction processes broadly useful
to biologists. |
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